Tragic Loss: Prince Frederik of Luxembourg Passes Away from Rare Disease – DW News, March 10, 2025

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Tragic Loss: Prince Frederik of Luxembourg Passes Away from Rare Disease – DW News, March 10, 2025

Prince Frederik of Luxembourg passed away at the young age of 22 due to a rare condition called POLG mitochondrial disease, as confirmed by his family. He died on March 1, and his parents shared the news through a statement on the POLG Foundation’s website.

“With a very heavy heart, my wife and I announce the passing of our son, Frederik,” said his father, Prince Robert. Frederik was the Founder and Creative Director of the POLG Foundation, dedicated to raising awareness about this disease.

Frederik was diagnosed with POLG mitochondrial disease at 14, a genetic disorder that severely impacts energy production in the body’s cells. This leads to progressive dysfunction in multiple organs. Unfortunately, there are no known cures or effective treatments for this condition. It can cause a variety of symptoms that affect many parts of the body.

The POLG Foundation describes the disease as akin to a “faulty battery” that never fully charges and ultimately runs out of power. Life with such a challenging condition can be daunting, but Frederik continued to show incredible strength and humor throughout his journey.

He bid farewell to his loved ones on February 28, which is also known as Rare Disease Day. His father recalled how, even in his final moments, Frederik’s humor and compassion shined through, leaving his family with one last laugh.

The impact of POLG mitochondrial disease highlights the importance of research and support for rare conditions. Frederik’s legacy will continue to inspire efforts to find better treatments for those affected.

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