Denver is facing a troubling rise in overdose cases, according to the latest data from the Denver Department of Public Health & Environment (DDPHE). The numbers for 2025 show an increase to 3,177 non-fatal overdoses, up from 2,620 in 2024.
Opioids are a significant part of this crisis. Overdose deaths have also risen, with 419 confirmed in 2025—a jump from 344 in the previous year. Ally Arnaiz, the Overdose Prevention and Education Program Coordinator at DDPHE, highlights a shift in the drug supply and the increased potency of substances as key factors putting individuals at risk. “When you see the drug supply change, and then an increase in the potency, that puts people at really high risk,” she explains.
Geography plays a role too. “We’re situated along the I-25 corridor,” Arnaiz notes, suggesting that trends from both coasts eventually reach Colorado. This delayed effect can significantly impact the local overdose situation.
Concerns about the unregulated drug supply are rising. Lisa Raville of HARM Reduction warns that focusing on arrests rather than treatment will not solve this issue. She argues that current legislation, which many see as a way to combat the opioid crisis, might actually worsen the situation by discouraging people from seeking help.
Despite ongoing efforts to improve access to treatment, barriers remain. In a positive step, the city is promoting free naloxone distribution at Denver Public Libraries, a tool that can reverse overdoses.
While the data paints a grim picture, it’s important to note that public awareness campaigns and community support are trying to make a difference. Finding effective solutions will be vital to turning around these rising trends.
For further information on naloxone and overdose prevention, check out the resources available at Denver Public Libraries.
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