Breakthrough At-Home Skin Cancer Tests: Early Insights from University of Michigan Researchers

University of Michigan researchers have created a simple, at-home test for skin cancer that works like a COVID-19 test. This innovative tool, called ExoPatch, was developed by a team led by Professor Sunitha Nagrath from the Nagrath Laboratory. The ExoPatch consists of a two-line strip test and a micro-needle patch designed to detect melanoma, a serious type of skin cancer.

The researchers utilized trials with mice to refine this home detection kit. When patients suspect they might have melanoma, they can apply the ExoPatch to their skin. After just 30 minutes, the patch collects interstitial fluid from the skin, which is then tested for cancer indicators using the strip test.

Yoon-Tae Kang, a former postdoctoral fellow, notes that this method could change how patients manage their health. “People want to take liquid samples from their bodies, like urine or blood. We hope to find markers for melanoma in these samples,” Kang said.

Traditionally, skin cancer detection involves a painful biopsy, where a sample of the skin is cut out and sent for lab analysis. Scott Smith, a UM doctoral graduate, argues that an at-home test is a much better option. “No one wants unnecessary cuts and scars,” he said. Plus, waiting months for a biopsy can be stressful. An at-home option could make early detection more accessible.

Nagrath emphasized that such kits would empower patients to monitor their skin health regularly. “You can test whenever you want, and it gives you peace of mind,” she explained. With melanoma responsible for a significant number of cancer deaths, early detection is crucial. According to the Cleveland Clinic, over 80% of melanoma cases are linked to excessive sun exposure, and about 30% arise from existing moles.

The ExoPatch is designed to be affordable, with low material costs, potentially making the kits available for a few dollars. Looking ahead, the team plans to test the patches on human subjects and seek funding to bring this innovation to market. They have also filed a U.S. patent.

Nagrath concluded, “Without investment in basic science and tech, we won’t reach those in need.” Innovations like this could revolutionize skin cancer detection and give more people the tools they need to take charge of their health.

For more information about skin cancer and its prevention, visit the Cleveland Clinic.

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