This week in Manchester, UK, scientists are debating the future of research into “mirror life”—synthetic cells made from molecules that are mirror images of those in nature. As excitement grows for this field, many researchers are also raising alarms about the possible dangers.
In recent discussions, John Glass, a synthetic biologist from the J. Craig Venter Institute, expressed that nearly everyone agrees that creating mirror-image cells could be harmful. There are concerns about how such cells could affect human health and the environment. Yet, the topic is still divisive. While some thinkers warn against jumping to conclusions, there is also a belief that exploring mirror molecules might unlock new medical therapies.
Chirality is key in this conversation. Many vital molecules in our bodies come in two mirror-image forms. For instance, proteins are made up of left-handed amino acids. Interestingly, these mirror molecules could remain stable in the body due to the immune system’s difficulties recognizing them, suggesting potential new drug paths. In 2017, the FDA approved etelcalcetide, a drug using mirror-image amino acids, to treat chronic kidney disease.
However, the benefits come with caveats. Some researchers worry that if mirror-image cells were created, they could grow unchecked, posing serious risks. Sven Klussmann from Aptarion Biotech argues it’s important to weigh the risks without rushing to halt research too soon. On the flip side, Kate Adamala, a synthetic biologist at the University of Minnesota, believes the dangers of delving into mirror biology outweigh any potential advantages. She argues there are safer routes to achieve similar benefits through traditional biology.
Historically, researchers had previously received grants to explore this area without fully understanding the risks involved. Since then, groups like the Mirror Biology Dialogues Fund have emerged, helping to navigate these complex discussions. At a recent meeting, experts were urged to avoid funding mirror cell research, highlighting the need for regulatory boundaries.
As this conversation continues, it’s essential to balance innovation with caution. The potential of mirror life is intriguing but requires careful examination to ensure that benefits do not come at an unacceptable cost. For further reading on the implications of mirror molecules, explore articles from Nature and the National Science Foundation.
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Cell biology,Chemical biology,Chemistry,Scientific community,Science,Humanities and Social Sciences,multidisciplinary
