Discover Revolutionary Proteomics Technology by MOBILion Systems at the US HUPO Conference – Insights by MyChesCo

CHADDS FORD, PA — MOBILion Systems, Inc. is gearing up to present at the 21st Annual US HUPO Conference in Philadelphia, PA, from February 22-26, 2025. The company is recognized for pushing the limits in separation science and will introduce its latest innovation, the Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF). Attendees can look forward to several scientific presentations showcasing this new technology.

Transforming Proteomics with PAMAF

PAMAF is a groundbreaking development in liquid chromatography-mass spectrometry (LC-MS), enhancing the speed, sensitivity, and accuracy of proteomics research. This technique replaces the traditional quadrupole isolation step with high-resolution ion mobility separation. As a result, it achieves fragmentation data with signal-to-noise ratios that are up to ten times better and operates about five times faster than older methods. PAMAF also maximizes ion use, making it especially useful for challenging samples, like those from single cells.

Dr. Melissa Sherman, CEO of MOBILion Systems, highlighted the benefits of PAMAF for health-related research. “Our PAMAF mode allows researchers to achieve more reliable measurements and detailed proteome analysis,” she noted. “With enhanced ion utilization, it supports workflows with limited samples while delivering exceptional accuracy.”

Key Scientific Presentations

During the conference, MOBILion will showcase how PAMAF improves complex proteomics workflows. Researchers will share findings on how this technology minimizes chimeric spectra, resulting in better protein quantification and analysis of modifications that occur after translation.

Highlighted sessions include:

• Oral Presentation (February 25): Dr. Daniel DeBord, CTO of MOBILion, will explain the benefits of forsaking the quadrupole for MS fragmentation at impressive speeds of 1,000 Hz with complete ion utilization.
• Posters (February 24-25): Topics will cover PAMAF’s efficacy in proteomics and its impact on high-throughput targeted analyses.

Focus on CKD Research

A standout event will be an educational breakfast seminar on February 26, featuring Prof. Birgit Schilling from The Buck Institute for Research on Aging. She will discuss her team’s insightful research on succinylation in a sirtuin-5 knockout mouse model related to chronic kidney disease (CKD). Thanks to MOBILion’s PAMAF platform, they identified numerous succinylation sites that may contribute to protective traits in kidney disease, highlighting the importance of advanced proteomics tools in biomedical research.

Pioneering the Future of Proteomics

Visitors are invited to meet MOBILion representatives at booth 18 to discover how PAMAF is transforming proteomics. By overcoming challenges like speed and sensitivity, MOBILion is setting new benchmarks in the industry.

With its innovations, MOBILion envisions a bright future for proteomics, offering tools that can deliver deeper insights into health and illness. PAMAF is poised to redefine research workflows, enabling scientists to explore complex biological issues with unmatched precision.