Exciting Global Partnership Set to Revolutionize Health Discoveries and Innovations

The University of California, Santa Cruz (UC Santa Cruz) is opening its cutting-edge cryogenic-electron microscopy (cryo-EM) facility to researchers from around the world, especially those in underserved areas like Africa. This means that scientists can access advanced technology without needing to spend millions on their own equipment.

What Is Cryo-EM?

Cryo-EM is a powerful method for studying the 3D shapes of proteins and other large molecules that are essential for life. It helps scientists understand how these structures contribute to health and disease. With support from the National Institutes of Health (NIH), UC Santa Cruz upgraded its equipment, installing a new electron microscope in late 2020.

The Impact of Collaboration

This facility not only serves UC Santa Cruz but also collaborates internationally with partners in six countries. Recently, the University of Cape Town and other institutions gained access thanks to the research-education network AmLight. This move is seen as a major step toward making structural biology more inclusive.

Jeffrey Weekley, director of research IT, mentioned that this initiative helps eliminate cost barriers, making it easier for researchers in Africa and other regions to take part in essential scientific work.

Successful Outcomes

Since its opening, the cryo-EM facility has helped solve 37 biological structures, leading to 13 publications. Researchers are using it to study important targets, including those related to influenza and respiratory viruses. Professor Rebecca Dubois, for instance, is using cryo-EM to identify weaknesses in viruses, which could lead to better treatments.

Sustainability Through Access

To keep the facility running, users are charged fees. UC Santa Cruz researchers enjoy discounts, while external users can apply for grants to help cover costs. This model ensures long-term sustainability for the facility, allowing it to continue supporting vital research.

In 2023, Vitor Hugo Balasco Serrão, the facility’s manager, received a substantial grant to fund training workshops on cryo-EM data processing. This initiative aligns with the university’s mission to enhance research impact globally.

A Stronger Future for Science

The cryo-EM facility is equipped with advanced tools that streamline the entire research process—from preparing samples to analyzing data. As a result, it serves about two dozen labs at UC Santa Cruz and 15 companies across six countries.

In September 2023, researchers from the University of Cape Town visited UC Santa Cruz to learn about the facility. They aim to establish a cryo-EM hub in South Africa, focusing on disease challenges specific to the continent, including HIV.

Jeremy Woodward, a structural biologist, highlighted the importance of this collaboration for accelerating scientific discovery. It not only provides advanced tools but also opens up opportunities for new vaccines and treatments that can tackle pressing health issues in Africa.

This global partnership represents a shift in how scientific research can benefit from collaboration, reminding us that great discoveries often happen when we break down barriers and share resources. For more information, you can visit the UC Santa Cruz Biomolecular cryo-EM Facility.

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