Top NFL Week 1 Betting Picks: Why You Should Fade Matthew Stafford and Smart Early Unders to Consider

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Top NFL Week 1 Betting Picks: Why You Should Fade Matthew Stafford and Smart Early Unders to Consider

The NFL regular season kicks off in 2025 with an exciting matchup: the Philadelphia Eagles defending their Super Bowl title against the Dallas Cowboys. It’s a thrilling time for football fans as we dive into the NFL Projection Model to find some great bets. The long offseason is finally over, and we get to enjoy two games before the first full Sunday lineup.

While I’m still weighing my options for both Thursday and Friday night games, I’ve got a teaser bet ready for the Thursday match. As for the Chiefs and Chargers game in Brazil, I might place a bet involving Travis Kelce.

For those new to my approach, I use an NFL Projection Model that analyzes play-by-play data to project team performances. This model evaluates offensive and defensive stats while adjusting for opponents and specific game situations. From this data, I can estimate the expected points and ultimately the spread for each game.

Last season’s record: 33 wins, 34 losses, 4 pushes; a slight loss overall.

To kick off the season, I’ve identified four bets. One is based on an injury, another feels risky, but the last two are bets I genuinely support. Let’s see how it goes!

NFL Week 1 Best Bets

New York Giants at Washington Commanders – Under 45.5 (-105)
The Giants are bringing in Abdul Carter, a versatile pass rusher, along with stars like Dexter Lawrence. I’m excited about the Giants’ defense, but the offense doesn’t instill much confidence. If they can control the Commanders’ Jayden Daniels, this game might end up being low-scoring.

Worst price to bet: Under 45 (-110)

Cincinnati Bengals at Cleveland Browns – Under 48 (-110)
Betting an under for the Bengals feels risky, but I believe their defense has the potential to improve this season. The Browns’ offense doesn’t exactly strike fear, which makes this an unappetizing but logical choice.

Worst price to bet: Under 47.5 (-110)

San Francisco 49ers at Seattle Seahawks – Over 43.5 (-105)
I’m nervous going for an over, especially considering injuries among wide receivers. Still, Christian McCaffrey has the power to revitalize the 49ers’ offense. If quarterback Sam Darnold can maintain last year’s performance, this game has great potential to go over.

Worst price to bet: Over 43.5 (-110)

Houston Texans +3 (-110) at Los Angeles Rams
This bet centers on Matthew Stafford’s back injury. While I’m not doubting his fitness, it’s reasonable to expect some rust since he missed significant training time. This matchup against a solid defense could be tough for him.

Worst price to bet: Texans +3 (-110)

Week 1 Teaser

Eagles -2.5 vs. Cowboys / Broncos -2.5 vs. Titans (-120)

Football’s renewal sparks excitement and anticipation. Fans are eager to see how teams adapt, especially those with new strategies or players. Engaging with the season through these bets adds a thrilling layer to the experience.

As always, remember to check multiple platforms for the best odds. Happy viewing!



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Cincinnati Bengals, Houston Texans, New York Giants, Seattle Seahawks, San Francisco 49ers, NFL, Sports Betting