Researchers have found that staying active before turning 50 can help keep your brain healthy as you age. A recent study from the Insight 46 project, which has tracked almost 500 people born in 1946 for nearly 80 years, reveals fascinating insights about exercise and brain health.
Dr. Sarah-Naomi James, from University College London, highlights that even light activities—like one leisure activity a month—can lead to a healthier brain later in life. Those who stayed active showed larger hippocampal volumes, the region crucial for memory, by the time they reached 70. Interestingly, even participants with early signs of Alzheimer’s disease performed better on cognitive tests if they were physically active, suggesting that exercise may toughen the brain against cognitive decline.
While most older adults lose about 1-2% of hippocampal volume each year, engaging in aerobic exercise could reverse this trend, effectively “buying” years of neurological youth. Studies link these benefits to improved blood flow and growth of new neurons, supported by brain-derived neurotrophic factor (BDNF), which is vital for learning and memory.
One notable aspect is that the Insight 46 study did not establish a direct connection between physical activity and the amount of amyloid plaques in the brain, which are often linked to Alzheimer’s. However, physical activity seemed to cushion the cognitive effects of these plaques. This phenomenon may be related to a concept known as “cognitive reserve,” which describes how active lifestyles can create backups in the brain. This helps maintain function even when faced with diseases.
The study also uncovered that women gained more from being active than men. Inactive women with amyloid deposits experienced greater memory loss compared to their male counterparts, but even a small amount of exercise helped narrow this gap. Researchers speculate that hormonal changes in women might make their brains more receptive to the benefits of exercise.
Public health guidelines recommend at least 150 minutes of moderate activity weekly, but even simple activities like walking or cycling count. Consistent movement is more important than intense workouts. Graham Kent, a 74-year-old participant in the study, emphasizes that running with friends keeps him active and connected, which highlights the social benefits of exercise.
In conclusion, incorporating regular exercise into your routine before 50 may pave the way for a healthier brain in later years. Movement matters—not just for your body, but for your mind. Remember, every step you take today can help protect your brain tomorrow. For more information on brain health and exercise, visit Alzheimer’s Research UK.

