Researchers are exploring an exciting new approach to improve cardiovascular health for individuals with spinal cord injuries (SCIs). These injuries can drastically impact a person’s mobility and overall health, leading to serious complications. One major issue is the dysfunction of the cardiovascular system, which is often triggered by disrupted nerve signals.
A recent study revealed that transplanting specialized cells from the nervous system may help regain nerve control over the heart and blood vessels. Shaoping Hou, who leads this research at the University of Missouri, explains how they harvested immature nerve cells from the spinal cord and brain stem. When these cells were transplanted to the injury site, participants showed signs of improved heart health, such as stabilized blood pressure and lowered heart rates.
However, the researchers noted that hormonal control over the cardiovascular system remained elevated. After an SCI, this increase in hormonal activity might be the body’s way of trying to restore balance, but it can lead to serious problems, such as stiffening blood vessels and increasing the risk of heart failure.
“The hormonal changes can damage the circulatory system,” says Hou. “We need to find a way to restore nerve function without relying too heavily on these hormonal signals.”
The potential for this treatment is significant, as it aims to safeguard cardiovascular health after an intense injury.
Statistics show that cardiovascular issues are among the leading causes of death in individuals with spinal cord injuries. Furthermore, a survey conducted by the National Spinal Cord Injury Statistical Center found that almost 50% of SCI patients experience cardiovascular complications. This highlights the importance of finding effective treatment solutions.
Moving forward, the research team plans to focus on how to maintain the benefits of nerve restoration while minimizing hormonal dependence. This work could truly change lives by protecting the heart health of those who have suffered SCIs.
For more details, check the study published in eNeuro and additional insights from the University of Missouri.
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