NASA and the China National Space Agency (CNSA) are gearing up for exciting journeys to Mars within the next decade. This ambitious goal is no small feat. It brings numerous challenges, especially when it comes to astronaut health and safety.
One major concern is the long trip to Mars. Astronauts will face radiation and the effects of being in microgravity for extended periods. Mars itself presents another set of hurdles. Its gravity is only about 38% that of Earth’s, which could pose long-term health risks for astronauts.
A team of international researchers is investigating how Martian gravity will affect a vital component of human health: skeletal muscle. This muscle is essential for movement and overall metabolic health, making it crucial for astronauts on long missions.
The research team includes experts from various institutions, including the University of Tsukuba and Japan Aerospace Exploration Agency (JAXA). Their findings were published in the journal Science Advances.
For their study, the team used 24 mice aboard JAXA’s Kibo module. They exposed these mice to different gravity levels—microgravity, 0.33 g, 0.67 g, and Earth’s 1 g—over a period of 28 days.
Before the experiment, mice underwent testing at NASA’s Kennedy Space Center. After returning, scientists analyzed their muscle condition and strength. Professor Marie Mortreux from the University of Rhode Island highlighted that simulating spaceflight on Earth is challenging. They found that 0.33 g closely mimics Martian gravity, providing insights into potential adaptations needed.
Their analysis showed that exposure to 0.33 g helped prevent muscle loss, while 0.67 g effectively maintained muscle strength. This suggests that mitigating muscle atrophy will be essential during the long journey to Mars.
Recent data shows that muscle atrophy can significantly impact astronaut performance and health. This research will help guide future space missions, ensuring astronauts remain fit and healthy. The findings also identified 11 metabolites in the mice’s blood that could serve as biomarkers for monitoring health in space.
This study builds on earlier work by Montreux and Professor Mary Bouxsein at Harvard, who explored the effects of reduced gravity on living organisms. They used similar models to monitor how muscles adapt to lower gravity environments.
Going forward, future Mars missions must consider ways to reduce skeletal muscle loss. Astronauts need to stay mobile and strong, not just for daily tasks but also for their safe return to Earth. Innovative designs like rotating toruses, inspired by NASA’s NAUTILUS-X concept, could be beneficial for this purpose.
By focusing on astronaut health, researchers are paving the way for successful exploration of Mars and beyond.

