Recent research suggests that long-term use of melatonin supplements, often seen as a safe solution for sleep troubles, might carry unexpected risks. A study set to be presented at the American Heart Association’s 2025 Scientific Sessions indicates that chronic insomnia patients using melatonin for a year or more may face a significantly higher risk of heart failure and related health issues.
Melatonin is a hormone made by the pineal gland. It helps control our sleep-wake cycles. When it’s dark, melatonin levels rise, promoting sleep, but they drop with daylight. Despite its natural origins, synthetic melatonin supplements are widely available over-the-counter. However, their safety isn’t tightly regulated, leading to differences in quality and effectiveness between brands.
In this study, researchers analyzed electronic health records from adults with chronic insomnia. They categorized participants based on whether they had documented melatonin use for at least a year. The findings were striking:
- Patients using melatonin long-term had a 90% higher likelihood of developing heart failure over five years compared to those who didn’t use it.
- Hospitalization rates for heart failure were also concerning; melatonin users were nearly 3.5 times more likely to be hospitalized.
- Additionally, the risk of death from any cause was almost double for melatonin users compared to non-users.
“This raises important questions about how we view melatonin as a safe sleep aid,” says Dr. Ekenedilichukwu Nnadi, the study’s lead author.
Experts emphasize that while melatonin is labeled as a natural sleep remedy, its long-term effects on heart health remain uncertain. Dr. Marie-Pierre St-Onge from Columbia University highlighted that melatonin is not recommended in the U.S. for treating insomnia. She expressed concerns about the number of patients using it for prolonged periods without sufficient supervision from healthcare providers.
Current estimates from the American Heart Association show that about 6.7 million adults in the U.S. live with heart failure, a debilitating condition where the heart cannot effectively pump blood. With such a prevalence, understanding the long-term impact of widespread melatonin use is crucial.
While the study provides vital insights, certain limitations exist. For example, it did not account for variations in melatonin consumption, especially in countries where it may require a prescription, like the U.K. Thus, individuals using over-the-counter versions may not be accurately represented.
In a rapidly evolving landscape of sleep aids and supplements, these findings underscore the need for further research. As we seek safe and effective ways to improve sleep, we must remain cautious about popular solutions like melatonin. Understanding the potential risks can help guide better choices for those struggling with sleep issues.
For more detailed information, please refer to the American Heart Association.
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Melatonin, Sleep, Supplements, Blood, Cardiometabolic, Chronic, CT, General Medicine, Heart, Heart Failure, Hormone, Insomnia, Jet Lag, Medicine, Nervous System, pH, Research, Stroke
