NFL 2025 Week 6 Update: Kyler Murray Confirmed Out for Cardinals – Who Else is Inactive?

Kyler Murray will not play in the upcoming game against the Colts, marking a tough moment for the Cardinals. He missed practice this week due to a foot injury, and although he showed up for a limited workout on Friday, he was officially ruled out shortly before kickoff.

In Murray’s absence, Jacoby Brissett will take the lead as quarterback, with Kedon Slovis stepping in from the practice squad to back him up.

Here’s a look at the player statuses for some key matchups:

Cardinals vs. Colts

• Cardinals: QB Kyler Murray, CB Elijah Jones, DL Darius Robinson, OL Demontray Jacobs, OL Josh Fryar, WR Xavier Weaver, DL Bilal Nichols
• Colts: RB Tyler Goodson, CB Kenny Moore, TE Will Mallory, WR Adonai Mitchell, QB Anthony Richardson, T Luke Tenuta, DE JT Tuimoloau

Rams vs. Ravens

• Rams: WR Tutu Atwell, LB Omar Speights, G Beaux Limmer, T Rob Havenstein, TE Colby Parkinson, DE Deshaun Johnson
• Ravens: QB Lamar Jackson, LB Roquan Smith, CB Chidobe Awuzie, FB Pat Ricard, T Carson Vinson, WR Tez Walker, DT Aeneas Peebles

Cowboys vs. Panthers

• Cowboys: WR CeeDee Lamb, OL Tyler Booker, WR KaVontae Turpin, LB Jack Sanborn, DL Mazi Smith, OL Ajani Cornelius
• Panthers: TE Ja’Tavion Sanders, CB Akayleb Evans, RB Chuba Hubbard, S Trevian Thomas, T Taylor Moton, DT Jaden Crumedy, DT Tershawn Wharton

Seahawks vs. Jaguars

• Seahawks: QB Jalen Milroe, S Julian Love, CB Devon Witherspoon, CB Riq Woolen, LB Derick Hall, OL Josh Jones, TE Nick Kallerup
• Jaguars: S Kahlef Hailassie, RB Cody Schrader, LB Yasir Abdullah, OL Robert Hainsey, DT Khalen Saunders

Chargers vs. Dolphins

• Chargers: WR Quentin Johnston, WR Derius Davis (knee), FB/DL Scott Matlock, OL Jamaree Salyer, T Joe Alt, OL Trey Pipkins, CB Nikko Reed
• Dolphins: QB Quinn Ewers, RB Jaylen Wright, CB Storm Duck, DT Zeek Biggers, LB Tyrel Dodson, WR Cedrick Wilson Jr., DB Elijah Campbell

Patriots vs. Saints

• Patriots: QB Tommy Devito, S Jaylinn Hawkins, LB Anfernee Jennings, DT Eric Gregory, G Caedan Wallace, DE Keion White
• Saints: S Ugo Amadi, CB Rejzohn Wright, OL Torricelli Simpkins, OL Xavier Truss, DT Khristian Boyd, CB Isaac Yiadom

Browns vs. Steelers

• Browns: CB Jarrick Bernard-Converse, RB Raheim Sanders, DT Mike Hall Jr., T Thayer Munford, G Zak Zinter, T Cornelius Lucas
• Steelers: WR Calvin Austin, S Chuck Clark, DL DeMarvin Leal, DL Logan Lee, OL Andrus Peat

Insights and Trends
In recent seasons, injury impacts on key players have dramatically shifted team dynamics. A 2021 study by the NFL Research Department found that teams missing their starting quarterbacks had a significantly lower win rate. This trend continues to play out, emphasizing the importance of player health in the league. As fans, we keenly watch these matchups, knowing how pivotal these players are.

Social media buzz around the league also highlights how injuries fuel fan sentiment. For instance, following Murray’s injury news, many fans took to Twitter to share their reactions, showcasing both concern and debate regarding the team’s strategy without him. This fan engagement reflects the depth of community surrounding NFL teams and their players.

Keeping an eye on how backup quarterbacks perform in these challenging situations will be interesting. Brissett has experience and could rise to the occasion, but it’s always a test. As the season progresses, how teams adapt will be crucial, making each game an exciting watch.

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