A research team from North Carolina has revealed a concerning link between sucralose, an artificial sweetener, and potential DNA damage. They discovered that a byproduct formed when sucralose is consumed, known as sucralose-6-acetate, may harm DNA and alter gut health.
Using human cells and lab-grown gut tissue, the researchers explored how this compound affects gene activity and the gut barrier. “Our findings establish that sucralose-6-acetate is genotoxic,” says Susan Schiffman, an expert in biomedical engineering at North Carolina State University.
What’s more alarming is that sucralose-6-acetate can be found in trace amounts in some retail products, even before consumption. This means that people’s exposure might be higher than previously thought because it can also form in the gut.
In tests, sucralose-6-acetate led to changes in gut cells. The gut barrier became less tight, allowing larger molecules to pass through. The research indicated that it caused DNA strand breaks, raising concerns about long-term health risks.
Experts emphasize the importance of understanding how much is too much when it comes to artificial sweeteners. European guidelines suggest a limit of 0.15 micrograms of genotoxic substances per person per day. The study implies that even one sucralose-sweetened drink might exceed this amount.
Sucralose was approved by the FDA in 1998, but regulatory checks have mainly focused on the sweetener itself, not its byproducts. Earlier safety studies did not explore modern biological responses to chemicals, and that’s a gap the new findings highlight.
Researchers call for a review of sucralose’s safety, especially since advancements in toxicology could reveal nuances that previous tests overlooked. They also suggest more studies on real-world exposure, which could involve tracking blood levels and gut health in people who regularly consume sucralose.
Changing your beverage choice can be a simple way to minimize potential risks. If you’re mindful of artificial sweeteners, you might want to explore unsweetened alternatives or drink more water. Always consult a healthcare professional if you have specific dietary concerns, especially if you’re taking medications.
This research was published in the Journal of Toxicology and Environmental Health, Part B. For more insights on health and additives, check out reputable sources like the FDA or World Health Organization.
